Abstract WP212: Arterial Stiffness is Associated With Apolipoprotein B 100, Not LDL-Cholesterol in Patients With Acute Ischemic Stroke

Abstract

Background: Arterial stiffness has been reported to be associated with hypertension, vascular disease including cerebral small vessel disease and increased mortality. Also, dyslipidemia is one of the potent risk factors for atherosclerosis. We aim to investigate the association of arterial stiffness and various lipid fractions including low density lipoprotein cholesterol (LDL-cholesterol), lipoprotein(a), and apolipoprotein B 100 in patients with acute ischemic stroke. Methods: We identified 2187 consecutive patients with acute ischemic stroke confirmed on MR imaging or CT. Brachial-ankle pulse wave velocity (baPWV) was measured using a volume-plethysmography device (VP-1000; Collin, Komaki, Japan). Lipid fractions were measured with blood sample taken after at least 8-hour fast. Vascular risk factors and demographics of patients were assessed by our prospectively collected stroke database. The association between baPWV and lipid fractions was tested using linear regression analysis. Results: Mean age of patients was 68.5 +/- 12.3 years and male was 1214 (55.5%). Mean baPWV was 20.85 +/- 5.55 m/sec. On simple regression analysis, baPWV was associated with lipoprotein(a) and LDL-cholesterol (p < 0.05). However, on multivariable linear regression adjusting for age, sex, lipid fractions and other vascular risk factors, apolipoprotein B 100 was the only significant lipid fraction for baPWV (beta 1.42; 95% confidence interval 0.45 - 2.40; p < 0.001). We included LDL-cholesterol instead of apolipoprotein B 100 in another model due to multicollinearity, which showed that neither LDL-cholesterol nor lipoprotein(a) was significant. Conclusion: Among lipid fractions, apolipoprotein B 100 is associated with systemic arterial stiffness in patients with acute ischemic stroke. Our finding suggests that apolipoprotein B 100 might be a better predictor for arterial stiffness than LDL-cholesterol and lipoprotein(a).