Abstract WP201: Sub-analysis of Japanese Versus Non-japanese on Background Characteristics and One-year Outcomes in Tiaregistry.org

Abstract

Background and Purpose: TIAregistry.org is an international prospective registry in patients with TIA or minor stroke (mRS 0 or 1) within 7 days after the onset. Main analysis of one-year follow-up data have been reported (N Engl J Med 2016;374:1533-42). We performed Japanese vs non-Japanese sub-analysis on the baseline and one-year follow-up data. Methods: Patients were classified into two groups according to their countries of origin (Japanese and non-Japanese). All comparisons between the two groups were adjusted on age, sex and mRS. Variables included demographic characteristics, intracranial and extracranial arterial stenosis, acute infarcts, TOAST classification, ABCD 2 score, and time to first contact. We compared the 1-year event rates of cardiovascular death, non-fatal stroke, and non-fatal acute coronary syndrome between the two groups using Cox proportional hazard models. Results: A total of 4,583 patients were included in the analysis. From them, 345 (7.5%) were Japanese. Proportion of patients with mRS 1 was higher in Japanese (58.5% vs 27.9%, p <0.001). The prevalence of acute infarct was higher for Japanese (73.9% vs 29.8%, p <0.001). Intracranial arterial stenosis >50% was more common in Japanese (19.6% vs 12.9%, p = 0.01). Distribution of ABCD 2 score was also different between Japanese and non-Japanese (20.1% vs 33.5% in scores 0-3, 28.6% vs 18.3% in scores 6 and 7, p = 0.02 in total). Time to first contact <24 hours was fewer in Japanese (80.0% vs 88.2%, P <0.001). Composite event rate of cardiovascular death, nonfatal stroke, nonfatal acute coronary syndrome was 7.7% in Japanese and 6.0% in non-Japanese (p = 0.18), while nonfatal stroke rate was higher for the Japanese patients (7.5% vs 4.4%, p = 0.008). Conclusions: Higher risk conditions in baseline characteristics as well as delay of time to contact, and a higher one-year stroke rate were identified in Japanese patients enrolled in this registry.