Abstract WMP52: Demographic Trends in Stroke-Related Mortality in Young Adults (Age:15-55 Year) With Concomitant Opioid Use in the United States From 1999-2020

Abstract

Background: The estimated range for the prevalence of Opioid Use Disorder (OUD) among adolescents and adults in the United States in 2019 was between 6.7 million and 7.6 million individuals. The overall mortality rate is increasing over the last 20 years. Objective: This study aimed to assess the trends in stroke-related mortality in chronic opioid users in different demographics in the United States. Methods: We analyzed Center for Disease Control and Prevention Wide-Ranging On-Line Data for the Epidemiologic Research database examined from 1999 to 2020 for multiple causes of death MCD-ICD 10 Codes. Stroke-related mortality rates, with and without opioid use, were stratified by age, sex, and race/ethnicity and expressed as age-adjusted mortality rates (AAMRs) per 100,000 persons. Annual percent change (APC) from 1999-2020 was calculated and graphically plotted. Results: Between 1999 and 2020, The were 307,615 stroke-related deaths and 358,322 opioid-related deaths occurred among adults (15-55), and 1615 deaths were related to stroke and opioid use. The age-adjusted mortality rate (AAMR) steadily increased from 0.1 in 1999 to 0.8 in 2020, with an annual percent change (APC):9.6 % (CI: 8.0-12.14). Men and women had unreliable differences from 1999 till 2011. Men had consistently higher AAMR than women from 2011 (AAMR men: 0.4 vs. women: 0.2; p:<0.005) to 2020 (AAMR men: 1.1 vs. women: 0.5 p:<0.006). Non-Hispanic (NH) Black or African American adults had the highest overall AAMR (0.5), followed by NH White (0.4), followed by Hispanic or Latino (0.3). Conclusion: There has been a steady increase in opioid-related Stroke mortality in the U.S. among adults 15-55 years with opioid use from 1999-2020. African American adults and men possessed the highest age-adjusted mortality rates (AAMRs) related to stroke with concomitant opioid use. Young adults require targeted stroke prevention and management strategies to reduce stroke-related mortality in the presence of concomitant opioid use.