Abstract WMP120: Does ICH Volume Affect Onset to Arrival Time?

Abstract

Background: ICH is a disease of high mortality. Increased hematoma volume has been associated with increased NIHSS severity and worse outcome. The purpose of this study was to determine if hematoma volume was correlated with time from symptom onset to time of hospital arrival. Methods: We conducted a review of consecutive acute ICH patients who were treated at UC San Diego from an IRB approved, prospectively collected UC San Diego Stroke Registry (1/2003-07/2016). All patients that presented as a “code stroke” within 12 hours and had ICH as the primary diagnosis were included in the analysis. Patients were allocated to time quartiles from symptom onset to arrival and compared between those quartiles for baseline demographic variables. A correlation matrix was built to assess variables that were correlated with ICH volume (mL). Variables with a p >0.10 were then included in a logistic regression to model. Results: The overall sample included 316 patients. Time from onset to arrival ranged from 25-720 minutes. The baseline demographics were significantly different amongst the time quartiles for: 1) history of atrial fibrillation (p=0.04); 2) current alcohol use (0.04); 3) and NIHSS (p=0.006). Patient in Q3 had the highest a-fib rates (20.5%). NIHSS was highest in Q1. ICH volume was significantly and positively correlated with age, history of HTN, current ETOH abuse, current SBP, and 90 day mRS (all p<0.05). ICH volume was not significantly correlated with time of arrival. Conclusion: This study supports the previous data of ICH volumes relationships to outcome. Other variables may be considered in ICH outcome scales to improve prognosis.