Abstract TP76: The Impact Of Registries In Stroke Literature

Abstract

Introduction: Registries represent a main source of data to the advances in medical literature. In stroke medicine, they serve as key points of discussion and elaboration for future clinical trials, as well as evaluation tools for several treatment modalities in different patient populations. We performed an analysis of recent stroke registries to evaluate their impact in literature. Methods: We performed PubMed and Google Scholar search using keywords with Boolean operators to identify studies deriving from stroke registries between January 2000 and June 2021. All registries identified were further characterized regarding study design, sample size, number of centers, number of peer reviewed articles or conference abstracts originating from it, with their respective number of citations and impact factor of journals. Results: A total of 51 registries were identified, comprising 43584 patients. Forty-three (84.3%) were prospective. Forty-five (88.2%) were multicenter. Sixteen (31.4%) focused in a specific device for mechanical thrombectomy. Twenty-seven (52.9%) were registered on clinicaltrials.gov. The most participating countries were United States in 16 (31.4%) and Germany in 8 (15.7%). Twenty-seven (52.9%) registries originated a total of 295 peer-reviewed articles, 6841 citations and a sum of impact factors of 1282.8. The median impact factor of journals publishing articles from registries was 5.51 (interquartile range, 3.27-7.91). The median number of citations per article was 13 (interquartile range, 4-37). Between registered and unregistered registries, there was no significant difference in the median number of publications (P=0.08), citations (P=0.158) or impact factor (P=0.124). Between registries specific and unspecific to a certain device, there was no significant difference in median number of publications (P=1.67), citations (P=0.631) or impact factor (P=0.509). Conclusions: Stroke registries provide a meaningful data source for literature regardless of registration or specificity to a certain device, and represent a key mechanism in the advances of stroke care. Contribution to stroke registries are key mechanism to elucidate clinical questions that require large sample size and should be incentivized.