Abstract TP52: Identification Of Thrombophilia(primary And Secondary) In Cerebral Infarction And Tia In The National Inpatient Sample 2016-2018

Abstract

Objective: To assess the identification of thrombophilia (primary and secondary) in cerebral Infarction and TIA in a nationwide database to determine the potential prevalence of this association Methods and Results: We assessed indicators of hypercoagulability in the National Inpatient Sample (NIS) database for all patients compared to those with cerebral Infarction and TIA from 2016 to 2018 to determine the potential diagnostic yield out of a sample size of 21 million subjects. During this timeframe, the frequency of thrombophilia was 0.6% in all patients compared to 1.2% in cerebral infarct patients. Grouping by age ≤45 compared to >45, thrombophilia was detected in 0.43% of those ≤45 compared to 0.67% in those >45. Despite the relatively low frequency of thrombophilia detected, the odds ratio (OR) was 13.5, 95% CI 12.7 - 14.18, (p <0.001) for cerebral infarction in those ≤45 compared to OR = 1.979, 95% CI 1.923 - 2.038, (p <0.001) in the >45 group. The OR was 12.4, 95%CI 11.916 - 12.95, (p <0.001) compared to 1.519, 95% CI 1.489 - 1.550, (p <0.001) for TIA patients in the ≤45 and >45 age groups, respectively. A higher prevalence of thrombophilia was seen in the Caucasians (68.9% p <0.001 in cerebral infarction, but not in TIA, 74.7% p <0.56. The prevalence was also higher in females (55.9%, OR = 1.29, 95% CI 1.207 – 1.373 p < 0.001) for cerebral infarction but not TIA, 65% p < 0.132. Conclusion: There is a greater propensity for thrombophilia in association with cerebral infarction and TIA in younger patients. Caucasians and females with thrombophilia were also observed to have a higher risk of cerebral infarction.