Abstract TP417: Minimally-Invasive Video-Assisted Ligation of Left Atrial Appendage in Atrial Fibrillation: Stroke Prevention Strategy

Abstract

Background: Non-valvular atrial fibrillation (AF) is a leading cause of embolic stroke, especially in the elderly population. The vast majority of thrombo-emboli in AF patients originate within the left atrial appendage (LAA). Effective and complete isolation of the LAA has been demonstrated to have a similar stroke-reduction effect as chronic anticoagulation. This study presents our initial experience with a novel minimally-invasive video-assisted (MIVA) thoracoscopic approach to epicardially isolate the LAA using the AtriClip device. Methods: Six consecutive AF patients (mean age 73.6 years, 3 of 6 male) with contra-indication to systemic anticoagulation underwent epicardial ligation of LAA using the AtriClip device. Procedure involved two 5mm ports and one 15mm port with application of the device at the base of the LAA under direct visualization. Immediate intra-operative confirmation of LAA isolation via trans-esophageal echocardiography (TEE) was obtained. Anticoagulation was not restarted post-operatively. Results: Average procedure length was 43mins and average length of stay was 72hours. All six patients had a non-complicated post-operative course. No stroke, myocardial infarction, renal failure or re-operation was encountered. No transfusions were needed. All patients were extubated in the operating room at conclusion of procedure and were ambulatory on the first postoperative day. 3 of 6 patients experienced excessive pleural drainage lasting 2-4 days postoperatively. TEE confirmation of complete LAA obliteration was achieved in all patients. Conclusions: MIVA LAA ligation appears to be a safe, effective and simple procedure to isolate the LAA in AF patients with contra-indication to anticoagulation. A multi-institutional trial to assess the efficacy of MIVA LAA ligation as a stroke prevention strategy is warranted and forthcoming.