Abstract TP262: Trends, Odds, Burdens and Outcomes of Metabolically Healthy Obesity in Stroke Related Hospitalizations of Elderly Patients - A Nationwide Analysis, 2016-2019

Abstract

Background: Obesity has been associated with an increase in the risk of stroke and poor outcomes. Meanwhile, Metabolically healthy obesity (MHO) trends are understudied in association with stroke. In this study, we aim to analyze the MHO trends and outcomes with respect to Stroke. Methods: We queried the National Inpatient Sample (2016-2019) to identify Stroke hospitalizations in the elderly population (%E2%89%A565 years) with vs without MHO by using ICD-10 codes after excluding patients with Hypertension, analyze, and Diabetes Mellitus. Patients were categorized into a metabolically healthy obese MHO+ve cohort, BMI> 30, and MHO-ve cohort, BMI<30. Trends, demographics, comorbidities, and outcomes were then compared between the two cohorts. Results: Overall Prevalence of stroke was higher in the MHO-ve cohort (2.4% vs 1.4% p<0.001) compared to the MHO+ve cohort. MHO-ve cohort often consisted of higher median age (78 vs 73 years), Males (48.2% vs 36.4%), Hispanics (5.1% vs 4.7%), whites (83.8% vs 82.3%), Asians (2.4% vs 1.1%) vs MHO +ve cohort (p<0.001). The rate of death (15.9% vs 14.4%), Home health care requirements (16.6% vs 12.4%) was also higher in the MHO-ve cohort vs MHO+ve cohort. Conversely, the MHO+ve cohort had higher rates of smokers, Prior MI, Hypothyroidism, CKD, and OSA in comparison to the MHO-ve cohort. Univariate and Multivariate regression analysis adjusted for confounders did not show any significant association between Stroke and MHO. Conclusion: Excluding other cardiovascular disease risk factors such as hypertension, diabetes mellitus, and hyperlipidemia, the non-significant difference in in-hospital mortality between elderly stroke patients with vs without MHO suggests that MHO might not be a significant independent predictor of short-term mortality. Other factors likely influence this relationship. Further research is warranted for the investigation of the factors influencing the absence of a relationship between stroke and MHO.