Abstract TP224: The Impact of Cerebral Microbleeds on Outcomes of Non-cardiogenic TIA and Minor Ischemic Stroke

Abstract

Background: The relationship between cerebral microbleeds (CMBs) and risk of early recurrence of ischemic stroke in patients with transient ischemic attack (TIA) or ischemic stroke is still controversial, and as is the effect for the prognosis. Our aim is to verify the relationship between CMBs and outcome in patients with TIA and minor ischemic stroke. Methods: We retrospectively reviewed consecutive patients with non-cardiogenic TIA and minor ischemic stroke (NIHSS <4 on admission), who underwent an initial brain MRI within 48 hours from symptom onset. The patients were divided into two groups according to presence and absence of CMBs and were compared clinical outcomes. Poor outcome was defined as modified Rankin scale 4-6 at 90 days after symptom onset. Logistic regression analysis was performed to determine the factors for outcome. Results: A total of 374 patients (279 men, median age 67 years old) were enrolled in our study. CMBs was observed in 152 patients (41%). Outcome was significantly poor in patients with CMBs (11% vs 3%, P=0.002). Stroke recurrence was frequently observed in patients with CMBs (13% vs 7%, P=0.041). Increased CMBs burden is lineally associated with poor outcome in comparison with absent CMBs (Figure 1). The multivariate analysis revealed that the CMBs was independently associated with poor outcome (OR, 3.86; 95%CI, 1.29-11.53; P=0.015). Conclusion: CMBs is the important factor for poor outcome in TIA and minor ischemic stroke, especially in increased CMBs burden patients.