Abstract TP208: Incidence and Outcome of Iatrogenic Stroke in Post-Menopausal Women

Abstract

Object: The incidence of iatrogenic stroke has not been determined in cohort studies. We determine the incidence of iatrogenic stroke in a large cohort of post-menopausal women. Methods: We analyzed the data for 93,676 women aged 50-79 years who were enrolled in the observational arm of the Women’s Health Initiative Study. We calculated crude and standardized incidence rates over a mean period (±SD) of 12±1 years. We calculated the incidences of iatrogenic and non-iatrogenic stroke adjusted for age and sex based on the 2010 US census. We compared the incidence of using standardized incidence ratio (SIR) with 95% confidence interval (CI). We estimated the 30-day case-fatality rates. Results: We identified 150 iatrogenic (141 ischemic and 9 hemorrhagic) and 2425 non-iatrogenic (1993 ischemic and 431 hemorrhagic) strokes. Age-standardized incidence rate per 100 000 was 48.9 (95% CI, 37.1- 6.25) for iatrogenic stroke and 741.9 (95% CI, 690.5 - 795.3) for non-iatrogenic strokes (SIR of 0.07). For ischemic stroke, the age adjusted incidence was 50.2 (95% CI, 38.8-64.8) for iatrogenic and 709.0 (95% CI, 658.2-762.6) for non iatrogenic stroke (SIR of 0.07). Thirty-day case-fatality rate was 9.3% (95% CI, 5.2-15) for iatrogenic stroke and 17.3% (95% CI, 15.7-19.0) for non iatrogenic stroke. Conclusions: The incidence of iatrogenic stroke was higher than previously anticipated and 1 of every 15 stokes in post menopausal women was iatrogenic in etiology