Abstract TP207: Do Women Have Lower Odds of In-hospital Mortality Compared to Men After Mechanical Thrombectomy for Acute Ischemic Stroke?

Abstract

Introduction: Published studies show a greater clinical benefit for intravenous thrombolysis for acute ischemic stroke (AIS) among women compared to men. It is not clear whether there are any sex differences in clinical outcomes following mechanical thrombectomy (MT) for AIS. Using a nationally representative database, we examined the influence of sex on outcomes after MT. Methods: We used the Nationwide Inpatient Sample from 2006-2014, a nationally representative data set of US hospital admissions, to identify patients with ischemic stroke. In-hospital mortality was compared between men and women using a logistic regression model that accounted for extraneous factors. Results: A total of 6,049 (weighted =30,137) patients with ischemic stroke and MT were included in this analysis. There was no significant difference in baseline characteristics between men and women except for older age among women. In a multivariable logistic regression model, women had statistically and significantly lower odds of in-hospital mortality (OR=0.846; 95% CI: 0.721- 0.996) after ischemic stroke and MT. Discussion: Women in the United States had 16% lower odds of dying in the hospital following MT for AIS. While this sex benefit corresponds to that that seen with IV thrombolysis, further investigation into its underlying mechanisms, especially in the era after the pivotal thrombectomy trials is warranted.