Abstract TP202: Sex-specific Differences In Risk Profiles For Cancer Among 19702 Japanese Patients With Ischemic Stroke: The Biobank Japan Project

Abstract

Background: There is limited data on sex-specific differences in subtypes and risk profiles of cancer among ischemic stroke patients. Methods: Among the subjects registered in the BioBank Japan database, 19702 ischemic stroke patients (n= 12241 male and n= 7261 female, median age 71 years old) were analyzed. We compared the prevalence of 20 cancer types between men and women. The multivariate logistic analysis was used to explore the association between risk factors and cancer by sex. Results: Any cancer was present in 1656 (8.4%) subsets of the overall cohort. The prevalence was highest for colorectal cancer (1.9%) followed by gastric cancer (1.6%), prostate cancer (1.2%), breast cancer (0.8%), and lung cancer (0.5%). Incidence was significantly higher in men than women for any (8.7% vs. 7.8%, P=0.029), colorectal (2.1% vs. 1.5%, P=0.003), gastric (2.0% vs. 1.0%, P<0.001), lung (0.6% vs. 0.4%, P=0.013), bladder (0.7% vs. 0.2%, P<0.001), pharyngeal/laryngeal (0.4% vs. 0.1%, P<0.001), and kidney (0.4% vs. 0.1%, P<0.001) cancer. By contrast, sex-specific cancer was more frequently observed in women than men (3.0% vs. 1.8%, P<0.001). In men, older age (ORs 1.80, 95%CIs 1.67-1.94, P<0.001], chronic renal failure (ORs 1.74, 95%CIs 1.24-2.46, P=0.002), atrial fibrillation or flutter (ORs 1.37, 95%CIs 1.07-1.76, P=0.014), and smoking (ORs 1.27, 95%CIs 1.09-1.48, P=0.002) were independently associated with cancer. In women, older age was the only independent factor associated with cancer (ORs 1.15, 95%CIs 1.05-1.25, P=0.002). Conclusion: Men have a higher prevalence of cancer including shared 6 anatomic sites, while sex-specific cancer was more common in women. Male predominance is largely explained by risk profiles including older age, chronic renal failure, atrial fibrillation or flutter, and smoking. These results indicate that cancer among stroke patients shares common risk factors for stroke or cardiovascular disease in men but not women.