Abstract TP197: Obstructive Sleep Apnea Associated With Lower All-Cause Mortality In Ischemic Stroke Patients

Abstract

Introduction: Obstructive sleep apnea (OSA) is a sleep disorder associated with cardiovascular risk factors similar to those associated with cerebral infarction (CI). Our aim was to characterize patient demographics and to investigate the effect of OSA in CI. Methods: Retrospective cohort study using 2019 National Inpatient Sample. Adults with diagnoses of CI and OSA were included. Primary outcome was all-cause mortality, and secondary outcomes were length of stay (LOS) and total charge in USD. Results: Out of 700175 CI patients, 49735 had OSA. Compared to Non-OSA-CI cohort, OSA-CI cohort were younger (67.38 vs 69.67 years,p<0.001) and had fewer females (37.36% vs 50.09%,p<0.001), Black (15.50% vs 17.38%,p<0.001), Hispanic (5.21% vs 8.26%,p<0.001), API (1.91% vs 3.15%,p<0.001), Medicaid (7.79% vs 10.26%,p<0.001), alcohol abuse (3.53% vs 4.75%,p<0.001), dementia (7.25% vs 12.06%,p<0.001), drug abuse (2.56% vs 3.33%,p<0.001), systolic heart failure (0.55% vs 6.36%,p<0.001), atrial fibrillation (1.12% vs 10.25%,p<0.001). OSA-CI cohort had more White (72.59% vs 65.58%,p<0.001), depression (17.25% vs 10.97%,p<0.001), chronic pulmonary disease (28.79% vs 16.25%,p<0.001), complicated hypertension (45.72% vs 33.57%,p<0.001), complicated diabetes mellitus (36.67% vs 23.80%,p<0.001), hypothyroidism (16.19% vs 14.02%,p<0.001), and obesity (43.22% vs 12.87%,p<0.001). OSA-CI cohort had lower all-cause mortality rate (4.32% vs 6.50%,p<0.001), mortality OR 0.73 (95%CI 0.65-0.81,p<0.001), lower mean LOS (6.17 vs 6.67 days,p<0.001), lower mean total hospitalization charge ($91,762.00 vs $99,993.00,p<0.001). Conclusion: Among patients admitted with CI, the presence of OSA was associated with lower all-cause mortality, odds of mortality, mean LOS and mean total hospitalization charge. OSA had a higher prevalence in younger White males and was associated with more depression, hypertension, diabetes mellitus, and obesity.