Abstract TP186: Associations Of Durations Of Antiplatelet Use And Vascular Risk Factors With The Presence Of Cerebral Microbleeds

Abstract

The association of the presence of cerebral microbleeds with antiplatelet use remains controversial. Long durations of antiplatelet use and vascular risk factors may have a greater effect on the development of microbleeds than short durations. Our aim in the present study was to determine whether the durations of antiplatelet use and vascular risk factors are associated with cerebral microbleeds. Two hundred twenty outpatients with cerebrovascular disease detected by MRI were examined. Cerebral microbleeds were observed in 71 (32.3%) patients, and deep or infratentorial microbleeds and strictly lobar microbleeds in 53 (24.1%) patients and 18 (8.2%) patients, respectively. To determine the association the between durations of vascular risk factors and antiplatelet use, radiological findings regarding the presence and location of cerebral microbleeds were assessed by multivariate logistic regression analysis adjusted for age, sex, and relevant confounders. The duration of hypertension, the presence of lacunar infarcts and the severity of periventricular hyperintensity were associated with microbleeds in a deep or infratentorial region. Antiplatelet use and its duration of were not associated with the presence or location of microbleeds. Our results suggest that deep or infratentorial microbleeds reflect the severity of hypertensive vasculopathy. Thus, antiplatelet use may not be associated with the presence of cerebral microbleeds.