Abstract TP185: Diuretic Use and the Risk of Vertebral Fracture After Stroke: A Population-based Cohort Study

Abstract

Introduction: Stroke is a major risk factor for vertebral fracture. Hypertension is a very common comorbidity observed in stroke patients, and diuretics have been widely used for the treatment of hypertension. Our study investigated whether treatment with thiazides or loop diuretics affects the risk of vertebral fracture after stroke. Methods: A population-based propensity-matched cohort study was conducted using the Taiwan National Health Insurance Research Database. Patients with a new diagnosis of stroke between 2000 and 2011 were included. After propensity score matching, 9468 patients were included in the analysis of the effect of thiazides, of who 4734 received thiazides within 2 years after stroke. To analyze the loop diuretic effect, 4728 patients were included, of who 2364 received loop diuretics. A Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) of vertebral fractures among patients according to thiazide or loop diuretic use within 2 years following stroke. Sensitivity analyses based on the duration of thiazide or loop diuretic use were further conducted. Results: There was no significant difference in vertebral fracture risk between thiazide users and non-users (adjusted HR [aHR] = 1.14, 95% confidence interval [CI] = 0.88–1.47, p = 0.316). Loop diuretic users had a significantly higher vertebral fracture risk than non-users (aHR = 1.45, 95% CI = 1.06–1.98, p = 0.019). However, the sensitivity analysis revealed that short-term thiazide use (exposure duration <90 days within 2 years after stroke) significantly increased the risk of vertebral fracture versus non-use (aHR = 1.38, 95% CI = 1.02–1.88, p = 0.039). Only short-term loop diuretic users had significantly higher risk of vertebral fracture (aHR = 1.56, 95% CI = 1.11–2.20, p = 0.011). The other two subgroups with longer exposure duration in analyses for both thiazides and loop diuretics revealed no significant effect. Conclusions: Short-term thiazide or loop diuretic use was associated with an increased risk of vertebral fracture after stroke. We believe that physicians should be aware of this potential association.