Abstract TP182: Bone Mass Loss May Be A Predictor Of Silent Cerebral Infarct And Cerebral White Matter Change In Community-dwelling Adults Without Stroke And Dementia.

Abstract

Background: Loss of bone and muscle mass, fall and fractures are common conditions after stroke. Possible association between reduced bone density and cognitive impairment in postmenopausal women are well recognized. However, the relationship between bone mass loss and silent infarcts and cerebral white matter changes remains unknown. Methods: Bone densitometry measured by Dual-energy X-ray absorptiometry of lumbar spine and hip and brain CT scan were performed for 650 subjects (458 female, mean age 63±7.8 years; 192 male, 61.5±8.5 years) among 650 stroke- and dementia-free adults older than 50 years recruited for early health check-up program, a part of PRESENT project between January 2009 and December 2010. Assessment of vascular risk factors and physical examination by in-person interview and were also taken by neurologist, and trained nurses. Result: In unadjusted analysis, the odds ratio (OR) for silent cerebral infarcts and/or cerebral white matter changes in men with osteoporosis was 3.8 (95% CI, 1.62-8.86; p = 0.002) and 2.2 (95% CI, 1.35-3.53; p=0.002) in women as compared to subjects with normal bone density. Even after adjustment for age, education, hypertension, DM, hypercholesterolemia, and current smoking, the OR was 3.8 (95% CI, 1.43-10.3; p = 0.008) for men and 1.9 (95% CI, 1.10-3.18; p=0.02), for women. Conclusion: These findings suggest that loss of bone mass may be a predictor of silent cerebral infarcts and cerebral white matter changes in community dwelling, apparently healthy adults.