Abstract TP177: Comparison Of Baseline Serum Glucose Concentration Between Fast And Slow Progressor Phenotypes Of Anterior Circulation Large Vessel Occlusion Stroke

Abstract

Introduction: The determinants of fast and slow progressor phenotypes of infarct growth in anterior circulation large vessel occlusion (ACLVO) remain poorly understood. Previous studies have shown a potential link between baseline serum glucose and acute infarct growth. We assessed whether presenting serum glucose is independently associated with fast or slow progression of infarct growth in ACLVO stroke. Methods: Retrospective analysis of patients with acute stroke due to intracranial ICA or proximal MCA occlusion across two comprehensive stroke centers from 2014-2019. Baseline CTP or MRI were obtained within 24hours of stroke onset. Fast progressors (ischemic core > 70ml, 0-6 h) and slow progressors (</= 30ml, 6-24 h) were identified. Serum glucose levels were compared in two groups: fast vs. non-fast progressors (0-6 h), slow vs. non-slow progressors (6-24 h). Mann-Whitney test was used for univariate group comparisons. Pearson correlation tested the association between serum glucose and infarct growth rate (core volume / time of stroke onset to imaging). Results: A total of 350 participants were included (n=178 imaged < 6 hours of stroke onset; n=172 imaged at 6-24 hours of stroke onset). Amongst early presenters, the median glucose was 127 mg/dL for fast progressors (n=32) versus 122 mg/dL in non-fast progressors (n=146), p=0.45. Amongst late presenters, the median glucose was 122 mg/dL for slow progressors versus 133 in non-slow progressors (p=0.085). The correlation between serum glucose concentration and infarct growth rate was 0.03 (p=0.57). Conclusion: While a numerical trend suggesting lower glucose levels was observed in slow progressors, no significant correlation between hyperacute serum glucose and infarct growth rate was established.