Abstract TP168: Stroke Risk Among Those With Prior Healthcare Associated Infections: A Case Control Study

Abstract

Introduction: Younger age groups demonstrate greater heterogeneity in stroke etiology compared to the older stroke population. Identifying novel risk factors in this population is a high priority. Methods: Our study utilized patient data from three urban Manhattan hospitals and one community hospital outside of Manhattan. Cases were adults with a stoke admission. Controls were adults with a trauma or orthopedic admission randomly matched 2:1 to cases on date of admission. Odds of stroke following an infection during the prior year as compared to those with no infection was assessed using unadjusted logistic regression and as a time-varying analysis using unadjusted and adjusted generalized estimating equations controlling for time, age, sex, race, hypertension, diabetes, renal failure Results: Our study included 8,983 stroke cases and 17,966 matched controls with a mean age of 68.9 and 61.2 years, respectively. Of cases 50.6% were female. 28.8% were non-Hispanic white, 31.4% had diabetes, 61.7% had hypertension and 21.7% had renal failure. Of controls, 50.1% were female, 30.7% were non-Hispanic white, 15.3% had diabetes, 36.1% had hypertension and 15.1% had renal failure. Within the 1 year prior, 21.5% of cases and 14.5% of controls had an infection. Those with an infection in the year prior had increased odds of stroke when compared to those with no infection (Table 1) with the greatest effect size seen in those ≤45 years old. Conclusions: Odds of stroke increases following a hospital-acquired infection, particularly in the young population. Odds by type of infection will be presented.