Abstract TP165: Functional Outcomes at Discharge After Intracerebral Hemorrhage in Young Adults: Comparison by Sex and Pregnancy Status

Abstract

Introduction: Intracerebral hemorrhage (ICH) is a major cause of maternal morbidity and mortality. While sex differences exist in clinical outcomes of ICH in young adults, it is not known if outcomes differ between pregnancy-associated ICH (PICH) and non-pregnancy-associated ICH (NPICH). Methods: We performed a cross-sectional analysis of 134 adults, aged 18-44 years, admitted to an urban academic medical center with non-traumatic acute ICH between 01/01/2012-12/31/2021. Participants were identified using an internally maintained stroke registry as well as data collected from the ICHOP (Intracerebral Hemorrhage Outcomes Project) study. We compared ICH outcomes between three exposure groups: PICH, NPICH in females, and NPICH in males. PICH was defined as ICH occurring during pregnancy or within 3 months postpartum. The primary outcome was mRS at discharge, with good outcome defined as mRS 0-2 and bad outcome as mRS 3-6. We used logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (95%CI) for the association of exposure group status with bad outcome, with non-pregnant females as the reference group. Results: Characteristics of the study population are detailed in the Table. Individuals with PICH had a lower proportion of chronic hypertension (p<0.0001) and smoking (p=0.02). Adjusting for age, hematoma volume, and ICH location, functional outcomes at discharge did not differ between groups (Figure). Conclusions: Functional outcomes at discharge after ICH were similar in young adults, regardless of sex or pregnancy status, despite a lower prevalence of vascular risk factors in patients with pregnancy-associated ICH.