Abstract TP129: Periventricular Hyperintensity On Magnetic Resonance Imaging Predicts Unfavorable Outcomes After Intracerebral Hemorrhage

Abstract

Background and Purpose: To determine the association between the markers of cerebral small vessel disease (CSVD) and cerebral brain atrophy evaluated by magnetic resonance imaging (MRI) and outcomes after intracerebral hemorrhage (ICH). Methods: Consecutive patients with ICH ≤72 h from onset to door who underwent MRI during the hospitalization were included. We evaluated the CSVD markers as white matter hyperintensities scale (separately scored by periventricular hyperintensity [PVH] and deep and subcortical white matter hyperintensity [DSWMH]), the number of cerebral microbleeds, the number of old lacunes, and enlarged perivascular spaces scale and the degree of cerebral brain atrophy as global cortical atrophy scale. An unfavorable outcome was defined as a modified Rankin Scale score of 3 to 6 at 3 months from onset. We evaluated whether markers of CSVD and cerebral brain atrophy all assessed by MRI could be associated with prognosis of ICH. Results: We screened 361 consecutive patients with ICH, including 231 patients (161 [70%] male, median age 62 years). Of 231 patients, 83 (36%) patients had unfavorable outcomes. PVH, not DSWMH, was independently associated with unfavorable outcomes (odds ratio 2.059, 95% confidence interval 1.029-4.120, p = 0.041, Figure). There were no significant relationships between other CSVD markers and cerebral brain atrophy and prognosis after ICH. Conclusions: Severe PVH on MRI might predict unfavorable outcomes after ICH.