Abstract TP111: The Role Of Hypomagnesemia In Acute Ischemic Stroke: Analyses Of The Mimic-iv Database

Abstract

Background/Objective: Hypomagnesemia is commonly seen in critically ill patients and may cause complications and increase mortality. The study is conducted to investigate the patient’s characteristics and outcomes of critically ill patients with acute ischemic stroke (AIS) and hypomagnesemia. Hypothesis: We hypothesize that patients with acute ischemic stroke (AIS) and hypomagnesemia associate with poor prognosis. Methods: Patients with AIS are identified in the Medical Information Mart for Intensive Care IV database from 2008 to 2019. Hypomagnesemia is defined as ≤ 1.5 mEq/L. Propensity score matching is conducted to balance clinical heterogeneity using age, sex, Charlson Comorbidity Index (CCI), Acute Physiology Score (APS) III. We measured the linearity association between the hypomagnesemia and in-hospital mortality using a restricted cubic splines model. Results: Totally, we included 1,486 patients with AIS (103 patients having hypomagnesemia). Compared with patients without hypomagnesemia, those with hypomagnesemia were older (69.6±12.6 v.s. 68.6±14.3; P = 0.477; Table 1) and had higher CCI (7.8±2.3 v.s. 6.8±2.7; P < 0.001; Table 1), and APS III (43.0±20.5 v.s. 39.5±19.0; P = 0.074; Table 1). After matching, 103 pairs were left. There is no difference regarding in-hospital mortality (14.6% v.s. 13.5%; P = 0.766; Table 1) between each two group, even after matching (14.6% v.s. 14.6%; P = 1.000; Table 1). There was a non-significant negative linear trend between hypomagnesemia and in-hospital mortality (Figure 1). Conclusions: Patients with hypomagnesemia have poor characteristics; however, hypomagnesemia is not a risk factor of in-hospital mortality.