Abstract TMP97: The Burden Of Neurological Diseases In Asia - An Analysis For The Global Burden Of Disease Study 2019

Abstract

Background: The global burden of diseases (GBD) of neurological disorders is increasing worldwide. The purpose of this study is to determine the burden of neurological disorders, including incidence, prevalence, death, disability-adjusted life-years (DALY), years lived with disability, and years of life lost between 1990 and 2019 in Asia regions. Methods: The GBD study is updated every year, and the most recent version provides the burden of diseases according to age, gender, and region from 1990 to 2019. Our study included 13 neurological diseases including stroke, Alzheimer's disease and other dementias, Parkinson's disease, brain and central nervous system cancer, idiopathic epilepsy, motor neuron disease, multiple sclerosis, migraine, tension-type headache, meningitis, encephalitis, tetanus, other neurological disorders. All rates were described as age-standardized using the GBD standard. Data were described using 95% uncertainty intervals (UIs) and changes from 1990 to 2019 as percent (95% UIs) provided by the GBD website. Results: In 2019, DALYs of neurological diseases were 64.4 million in South-East Asia (95% UI 45.2-94.2) and 85.0 million in Western pacific regions (95% UI 63.0-118.5). The three neurological diseases with the highest DALYs in WHO South-East Asia and WHO Western pacific regions in 2019 were stroke, migraine, Alzheimer's disease and other dementias. DALYs of stroke and Alzheimer's disease and other dementia, Parkinson’s disease, brain and central nervous system cancer, multiple sclerosis, migraine, and tension type headache increased in both regions in 2019 compared to 1990. Infectious diseases such as tetanus, meningitis, encephalitis decreased in both regions. The age-standardized rate of stroke incidence (-10%, 157 to 141 in South-East Asia, -12%, 211 to 186 in Western Pacific) and mortality (-30%, 135 to 95 in South-East Asia, -42%, 180 to 104 in Western Pacific) decreased markedly in both regions. Conclusion: This study demonstrated the burden of neurological diseases in Asia. To reduce the burden of neurological disease, a strategy suited to the reality of each country will be needed, and this study can serve as the cornerstone of the strategy.