Abstract TMP51: Clinical Factors Associated With Enlarged Perivascular Spaces in a US Population of Caucasian Descent

Abstract

Introduction: Enlarged Perivascular Spaces (EPVS), characterized by distinct cerebrospinal fluid-filled structures surrounding intracranial vessels, have garnered growing attention concerning brain aging and cerebrovascular disorders. This study investigates the associations between EPVS and a spectrum of clinical factors and conditions in a large community-based sample in the northeastern United States. Method: This research was conducted on a subset of the Geisinger DiscovEHR Initiative Cohort. The total numbers of EPVS were categorized into five grades (0-4) in centrum semiovale and basal ganglia regions. A comparison was established between patients with EPVS and a propensity-score-matched cohort devoid of EPVS. Matching factors included age, gender, body mass index, and hypertension. Results: Among 3054 randomly selected participants (mean age 67.5 years, 57.4% women), 1465 (47.9%, mean age 69.6 years, 58% women) exhibited EPVS in their brain imaging. The presence of EPVS was linked to cerebral aneurysm (OR, 2.40; 95% CI, 1.5-4.0), heart failure (OR, 2.0; 95% CI, 1.5-2.8), peripheral vascular disease (OR, 1.5; 95% CI, 1.1-2.15), Parkinson's Disease (OR, 1.9; 95% CI, 1.2-3.1), history of ischemic stroke (OR, 1.18; 95% CI, 1.0-1.4), non-central nervous system malignancies (OR, 1.4; 95% CI, 1.1-2.0), smoking (OR, 1.3; 95% CI, 1.0-1.6), and warfarin use (OR, 0.76; 95% CI, 0.6-0.9). Higher scales of EPVS were notably associated with obstructive sleep apnea (OR, 1.9; 95% CI, 1.0-3.8) and hypertension (OR, 3.1; 95% CI, 1.1-9.9). Conclusion: EPVS presence and severity may be associated with several vascular risk factors, providing potential avenues for risk assessment and further research.