Abstract T P99: Elevated Fasting Glucose as a Potential Predictor for Asymptomatic Cerebral Stenosis: A Cross-Sectional Study in Chinese Adults

Abstract

Purpose: Cerebral Stenosis is known as an important cause of stroke, and elevated fasting glucose level is traditionally supposed as a risk factor for stroke; however, it is doubtful whether elevated fasting glucose is associated with cerebral stenosis, especially with asymptomatic cerebral stenosis . Methods: 5,309 participants with age of 40 years or older, free of stroke, transient ischemic attack, and coronary disease, were enrolled in this study from 2010 to 2011. Information of potential risk factors for cardiovascular disease were collected and cerebral stenosis was assessed by Doppler ultrasound. Participants were classified into four subtypes: non-cerebral steosis (NCS), intracranial artery stenosis (ICAS), extracranial carotid stenosis (ECCS) and combined intracranial and extracranial carotid stenosis (IECS). Fasting blood glucose (FBG) was also stratified into normal fasting glucose (FBG<5.60mmol/L), impaired fasting glucose (IFG) (FBG: 5.60-6.99mmol/L) and diabetes (FBG>6.99mmol/L) groups. The IFG group was further divided into IFG1 and IFG2 at cutpoint of 6.10mmol/L. A multivariate logistic regression was used to examine the association between FBG and cerebral stenosis. Results: FBG levels were significantly higher in ICAS and IECS groups than the other two groups. In multiple regression analysis, IFG2 level was the risk factor for ICAS (OR 1.50, 95%CI 1.10-2.06), and diabetes level was a powerful predictor for ICAS (OR 1.82, 95%CI 1.43-2.31) and IECS (OR 2.22, 95%CI 1.36-3.62). However, the paper finds fasting glucose level was not a risk factors for ECCS. Conclusions: The results suggest that elevated fasting glucose level is associated with asymptomatic cerebral stenosis, especially with ICAS and IECS, which suggesting the importance of fasting glucose control in the prevention of asymptomatic cerebral stenosis.