Abstract T P313: Sex-age Interactions and Differences in Outcomes After Intracerebral Hemorrhage

Abstract

Background: Compared to ischemic stroke, sex differences in outcomes after intracerebral hemorrhage (ICH) are largely unexamined. Methods: In the Get With The Guidelines (GWTG)-Stroke database, differences between men and women with ICH were assessed. Data from 192,826 patients with ICH admitted between January 1, 2009 and March 31, 2014 to 1,728 AHA-GWTG-Stroke fully-participating sites were analyzed. Logistic regression was used to assess age and sex interaction with respect to outcomes while adjusting for potential confounders. Due to missing stroke severity data in 52.5% of patients, models were performed with and without adjusting for NIHSS. Results: In the total study population, 48.9% were women (median age 75 years; male median age 67 years). On admission, women with ICH had lower creatinine and were less likely to smoke than men, and women over 65 years of age were less likely to have atrial fibrillation or dyslipidemia, use antiplatelets or cholesterol-reducers, but more likely to have higher admission NIHSS than men over 65 years. In the primary model, as age increased, odds for combined mortality and discharge to hospice were similar for men and women, but odds for discharge to home and independent ambulation at discharge increased more in men, with significant sex-age interactions (See Table). In the subset with NIHSS, similar adjusted sex differences were seen for mortality and length of stay but were non-significant for discharge to home and independent ambulation. Conclusions: After ICH, men experience higher odds of discharge to home and independent ambulation for each 10-year increase in age compared to women, after adjusting for covariates.