Abstract T P118: Left Ventricle Ejection Fraction as Prognostic Factor of Functional Outcome in Ischemic Stroke

Abstract

Background: Ischemic stroke is a leading cause of functional disability worldwide. Few studies have evaluated the relationship between Left Ventricle Ejection Fraction (LVEF) and the functional outcome after ischemic Stroke, however it has been shown that there is an important correlation between LVEF and Cerebral Blood Flow (CBF). The effects of LVEF on CBF may have critical implications on the post-ischemic brain. Objective: To determine if LVEF can be used as a prognostic factor in ischemic stroke Methods: We carried out a prospective, analytic, cohort study. We included stroke patients from our Neurovascular Resgistry (iReNe). We only included patients with complete information and that agreed to participate in the study. LVEF was measured during patients’ in-hospital stay. Clinical Follow up was done at 3 and 12 months using the modified Rankin Scale (mRs). Results: We included 129 patients with follow up at 3 months, from these, 69.5% of them had follow up at 12 months. Our study population was composed of 65.9% males, the mean age was 62.88 ± 13.18, 60.5% had hypertension, 49.6% diabetes mellitus, 27.9% dyslipidemia. Stroke subtypes according to TOAST were 38% atherothrombotic, 27.1% small vessel disease, 21.7% Cardioembolic and 13.2% were undetermined. The proportion of patients that died was 9.3%. We found that patients with good functional outcome (mRs 0-3) at 3 months had a mean LVEF of 57.22 vs an mean LVEF of 53.13 for the patients in the poor functional outcome group (mRs 4-6), p=0.020; Patients with good functional outcome (mRs 0-3) at 12 months had a mean LVEF of 57.38 vs 49.29 for patients with poor functional outcome (mRs 4-6), p=0.029. After performing a multivariate logistic regression analysis adjusted for sex, age and admission NIHSS, we found that LVEF maintained statistical significance. Conclusions: We found that a reduce LVEF is a factor of long term poor functional outcome in patients with ischemic stroke. Our results suggest that even relatively small reductions in LVEF may have a detrimental effect in recovery after ischemic stroke.