Abstract T P11: What Clinical Factors Predict An Intracranial Arterial Stenosis Responsible For An Intracranial Larger Artery Occlusion Treated By Endovascular Therapy?

Abstract

Objectives: In Asian countries where intracranial arterial stenosis (ICAS) is a common etiology regarding large artery intracranial occlusions in stroke. We sought to identify any clinical, laboratory and baseline imaging variables that may predict ICAS prior to endovascular treatment compared with angiographically-defined embolism (ADE). Methods: Patients were included if they had large cerebral artery occlusion in stroke on CT angiography and undertook transfemoral cerebral angiography, and if their onset to puncture time was within 8 hours. We defined ICAS and ADE by transfemoral cerebral angiography. ICAS was defined as fixed significant (> 50%) focal stenosis in the occlusion site, which could be seen in the final angiography or during the procedure of endovascular treatment. ADE was defined by no focal stenosis was evident after some recanalization achieved. Patients were excluded if their cause of stroke was associated or combined with other etiologies. Results: Finally, a total of 157 patients were included for this study. Table shows comparisons of clinical laboratory and imaging characteristics between ICAS and ADE groups. Patients in ICAS group were younger and male-predominant than in those in ADE group. Dyslipidemia and smokers were more frequent in ICAS group. Total cholesterol level was higher in ICAS group than in ADE group. Compared to ADE an ICAS was much more common in the posterior circulation 11/30 versus only 12/127 in the anterior circulation (p<0.001). Independent predictors of ICAS on multivariable analysis were male gender (odds ratio 6.34 [95% CI, 1.23-32.85], p=0.028), posterior circulation involvement (5.37 [1.62-17.82], p=0.006) and total cholesterol level (1.02 [1.004-1.033], p=0.012). Conclusion: The neurointerventionalist should prepare for the possibility of ICAS when performing endovascular treatment especially with posterior circulation occlusions in a Korean population.