Abstract
Abstract Malignant cellular function is maintained by a functionally altered proteome. Helping the proteome in this context is the chaperome, a network of molecular chaperones and folding enzymes. This talk will discuss how, by using chemical tools that selectively target the stress chaperome, one may perform mechanistic and therapeutic investigations into the tumor proteome. Specifically, using chemical tools as affinity-purification baits or as global perturbers of the altered proteome one may inquire into its nature (i.e., identify and investigate). By attacking specifically the stress chaperome, one may inactivate the altered proteome, and thus revert or slow the disease phenotype (i.e., treat). In summary, I will discuss how by chemically sensing the stress chaperome one may investigate, understand and destabilize the tumor proteome. Citation Format: Gabriela Chiosis. Understanding the proteome through the chaperome: From mechanisms to diagnostics and drugs. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr SY30-02. doi:10.1158/1538-7445.AM2015-SY30-02
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