Abstract
Abstract Despite the fact that natural products are attractive resources for the discovery of drug candidates, the screening processes often not only time-consuming and labor-intensive but also high risk to obtain potent molecules. We have previously devised a new means to reprogram the genetic code, which allows us to express macrocyclic peptides using a custom-made in-vitro translation system. Its integration with the mRNA display technique has also led to the development of a means of selecting bioactive macrocyclic peptides, referred to as RaPID (Random non-standard Peptide Integrated Discovery) system. This lecture will describe some of recent examples for the discovery of such natural product-inspired macrocycles and pseudo-natural products with their therapeutic applications. Citation Format: Hiroaki Suga. Natural product-inspired peptide drug discovery accelerated by the RaPID system. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr SY05-03. doi:10.1158/1538-7445.AM2014-SY05-03
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