Abstract PR416

Abstract

Background & Objectives: Acute kidney injury (AKI) is a serious complication after liver transplantation, the incidence of AKI after liver transplantation (LT) is more than 50%. Currently, the determination of AKI is used in accordance with Kidney Disease Improving Global Outcomes (KDIGO) AKI Work Group standard (2012). So, we concerned the question about the sensitivity and specificity of serum test results between Cr, BUN, UA, and β2-MG in the evaluation of AKI. Materials & Methods: We conducted this multicenter observational retrospective study of patients underwent LT from July 2003 to December 2013 in Beijing Chaoyang Hospital, Capital Medical University and General Hospital of the Armed Police Forces and Beijing You An Hospital, Capital Medical University. The diagnostic values of Cr, BUN, UA, and β2-MG were discussed by using ROC curves. The incidence of AKI after surgery according to KDIGO standard was defined by the calculated Cr increased occurrence at 1, 3, and 7 days and was taking the highest level by grade (stage I, stage II, or stage III). Results: 1636 cases were included in the study and 36 patients were excluded for incomplete data of pre- or postoperative labs. ROC curves of Cr, BUN, UA, and β2-MG for the diagnosis of AKI were drawn, and the areas under the ROC curves (AUCs) were as follows: 0.847 (P < 0.001), 0.713 (P < 0.001), 0.703 (P < 0.001), and 0.686 (P < 0.001). Cut-off points for AKI for Cr, BUN, UA, and β2-MG were 0.93 mg/dL (sensitivity: 80.05%, specificity: 75.72%) and 16.11 mg/dL (sensitivity: 54.24%, specificity: 77.52%), 4.34 mg/dL (sensitivity: 64.82%, specificity: 67.30%), and 3.39 mg/L (sensitivity: 60.84%, 69.60%), respectively.Conclusion: To predict AKI after LT, Cr had higher sensitivity and specificity compared to BUN, UA, and β2-MG.