Abstract PR404

Abstract

Background & Objectives: In Japan, 5-HT3 receptor antagonists are not mainstream in Post Operative Nausea and Vomiting (PONV) and traditional antiemetic agents are popular at present. In this study, we compared Granisetron and Metoclopramide to investigate their antiemetic effects after the emergence of PONV. Materials & Methods: 175 patients who had received laparoscopic cholecystectomy or ovarian cystectomy were included. Within two hours after surgery, patients’ PONV were evaluated using Visual Analog Scale (VAS) from 0(nothing) to 10(maximal). When patients’ PONV were VAS≥3, 1mg Granisetron (Group G) or 10mg Metoclopramide (Group M) was administered. The group allocation was due to the patients’ decision. In Group M, if the PONV continued VAS≥3, further Granisetron was given and VAS was evaluated again. Results: 48 patients had PONV (VAS≥3) which was 27.4% in all patients (Male:17.5% and Female:32.2%). 27 and 21 patients were allocated to Group G and M respectively. The mean VAS(≥3) was 5.0±2.3 in Group G and 5.6±2.1 in Group M before giving the agents. After giving the agents, VAS changed to 2.1±1.5 in Group G and 2.3±2.5 in Group M which showed no significant difference. The mean VAS in those who continued PONV(VAS≥3) in Group M changed from 6.3±2.1 to 4.2±2.2 after further Granisetron was given which showed significant difference. Conclusion: Antiemetic effect had no significant difference between Granisetron and Metoclopramide after the emergence of PONV, but if the patients’ PONV continued after given Metoclopramide, additional Granisetron seemed effective. Disclosure of Interest: None declared