Abstract
Background & Objectives: Background: Magnesium (Mg) is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist with antinociceptive effects. At high doses, perioperative intravenous magnesium sulfate has been reported to potentiate muscle relaxation and to reduce postoperative morphine consumption. When magnesium sulfate is co-administered with propofol, it potentiates the anesthetic effect and NMDA antagonism of propofol. These characteristics of magnesium (anesthetic- and analgesic-sparing effect) enable anesthesiologists to reduce the use of anesthetics during surgery and the use of analgesics after surgery. Thus Effective postoperative analgesia may facilitate recovery and reduce morbidity in surgical patients by blunting autonomic, somatic, and endocrine reflexes.Objective: double-blind prospective study to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing urologic surgery. Materials & Methods: 28 patients who underwent urologyc surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 30 mg /kg i.v. as a bolus and then 15 mg/kg/h i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. All patients were induced by fentanyl (2 μg/kg), propofol (1.5-2 mg/kg) and rocuronium in a dose of (0.6 mg/kg) to facilitate tracheal intubation. This was followed by continuous infusion of propofol (6-10mg/kg/h) and fentanyl (1-2 μg/kg/h). Results: Results showed that total consumptions of fentanyl, propofol and rocuronium were significantly less (P < 0.05) in magnesium group when compared to control group. Postoperative pain score as well as total analgesic requirement of morphine was significantly lower (P < 0.05) in magnesium group compared to control group. Conclusion: Magnesium sulfate reduces the total anesthetic and analgesic requirements and improved the quality of postoperative analgesia. Disclosure of Interest: None declared
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