Abstract PR01: HPV genotype distribution and cervical intraepithelial neoplasia in African American and white women living in the Southeastern United States

Abstract

Abstract Background: Differential distributions of oncogenic HPV genotypes among racial/ethnic groups may explain observed disparities in ICC incidence and mortality rates. We describe HPV genotypes associated with CIN1-3 in a multiethnic cohort of women visiting colposcopy clinic following a cervical abnormality. Methods: We enrolled 516 women attending colposcopic evaluation following an abnormal liquid-based cytology screen. HPV infection was measured using HPV linear array that measures 37 HPV types, and chi-squared tests were used to compare HPV genotypes in African American and Whites overall, and by CIN stage. Results: Of 516 participants, 373 (72%) were HPV-positive; 137 (37%) had no CIN lesion, 174 (47%) had CIN1, 38 (10%) had CIN2, and 24 (6%) had CIN-3. Twenty-seven percent of women were infected with one HPV genotype, and 73% were infected with multiple HPV genotypes. In women with CIN1, 75% of HPV single infections were of high risk (HR) genotypes, and 70% of women had multiple HR-HPV genotype infections. The most frequent HR-HPV genotypes detected among CIN1 cases were 16, 18, 31, 45, 52, 56, 59 and 66 in White women, while HPV subtypes 33, 35, 58 and 68 were the most common in African American women. Restricting analyses to women with CIN2-3 revealed a change in HR-HPV genotype distribution; HR-HPV 16, 18, 33, 35, 39, and 59 were most common in White women with CIN2-3, whereas HR-HPV 31, 45, 51 and 66 were the most prevalent in African American women. Conclusion: Our data suggest that while HPV 16 and 18 are the most common genotypes among women with CIN in Whites; African Americans may harbor different genotypes. The preponderance of non-16/18 HR-HPV genotypes in African Americans with increasing CIN grade has implications for both reflex testing following cytological abnormalities and vaccine development. This abstract is also presented as Poster B11. Citation Format: Adriana C Vidal, Jennifer S Smith, Edwin Iversen, Fidel Valea, Rex Bentley, Margaret Gradison, Kimberly Yarnall, Anne Ford, Francine Overcash, Katherine Grant, Susan Murphy, Cathrine Hoyo. HPV genotype distribution and cervical intraepithelial neoplasia in African American and white women living in the Southeastern United States. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr PR01.