Abstract PO-190: Prevalence and predictors of obesity-related cancers amongst racial/ethnic groups with metabolic syndrome

Abstract

Abstract Background: Obesity-related cancer (ORC) accounts for 40% of all cancer diagnoses in the United States and are associated with higher amounts of body fat (BMI ≥25), which could increase the risk of developing cardiovascular disease (CVD). CVD remains the leading cause of death in cancer survivors and its associated risk tends to cluster into interrelated groups of conditions commonly known as the metabolic syndrome (MetS). Therefore, further insight on groups at risk for developing CVD within the ORC and MetS population is warranted. Previous studies identified the prevalence of ORC to be higher in non-Hispanic Blacks and Hispanics compared to non-Hispanic Whites. However, prior studies did not control for sociodemographic and lifestyle factors that can differ across race/ethnicity. The purpose of this study was to compare the prevalence of ORCs by race/ethnicity among the adult (>18) cancer population with MetS represented in the 1999-2014 NHANES Survey and to identify predictors associated with having an ORC among adults with MetS. Methods: MetS was defined using the National Cholesterol Education Program (NCEP) Adult Treatment Panel-III (ATP-III) guidelines. Cancer type was self-reported and further classified as ORC or non-ORC. A chi-square test was performed to determine prevalent differences in ORC between Non-Hispanic White, Non-Hispanic Black, and Hispanic participants with comorbid cancer and MetS. A multivariate logistic regression was utilized to evaluate predictors (race, sex, income, insurance, education, marital status, and smoking status) of ORC among adults with comorbid cancer and MetS. Results. Of the 1,554 adults with MetS, the prevalence of ORC was 30.6% in non-Hispanic Whites, 51.3% in non-Hispanic Blacks, and 54.1% in Hispanics (p=<0.001). Three of the eight predictors were significantly associated with ORC. For every one-year unit increase in age, the odds of ORC increased by 3% [95% CI (1.00- 1.05), p=<0.01]. Females were 6.27 times more likely to have an ORC compared to males [(95% CI (4.95-14.11), p= <0.0001]. Lastly, when compared to non-Hispanic Whites, Non-Hispanic Blacks were 2.1 times more likely to have an ORC [(95% CI (1.40-3.38) p= <0.001]; and Hispanics were 2.5 times more likely [(95% CI (1.39-4.77), p=<0.01]. All other factors were insignificant. Conclusions. Among NHANES participants with MetS, the prevalence of ORCs was significantly higher in Blacks and Hispanics compared to Whites. In addition, ORC risk was reduced for males and younger adults with MetS. Future studies on the long-term impact of MetS on persons with ORC by race/ethnicity are warranted. Citation Format: Shanada Monestime. Prevalence and predictors of obesity-related cancers amongst racial/ethnic groups with metabolic syndrome [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-190.