Abstract PO-140: Medication use and environmental risk factors associated with prostate cancer among West African men

Abstract

Abstract Prostate Cancer (CaP) is one of the major causes of cancer death in West African Black men and the objective of the study is to evaluate the association of environmental risk factors and CaP among West African men. This cross-sectional study was conducted using CaPTC familial cohort study questionnaire to collect data from 500 participants from Nigeria, Cameroon, and the United States. Variables measured included: Social demographics, smoking behavior, exposure to second- hand smoke, exposure to pesticides, use of medication, alcohol consumption, diet, and CaP status. Respondents who smoke more than 100 cigarettes in their lifetime was considerate to have high smoking behavior. Those who were exposed to smoke when someone else other than them was smoking at home, work, school, and public places had high exposure to second-hand smoking. If the respondents worked on a farm for at least 10 years and was exposed to chemical fertilizers or pesticide, they were considered to have high exposure. Taking certain medication at least twice a week for a period of 6 month at the recommended or a higher dose had high risk. Respondents who had their first drink before the age of 15 and consumed alcohol for at least 6 months had high consumption status. Using the Dutch dietary guidelines, daily consumption of food was categorized into 12 groups, 9 had positive health effect and 3 had negative health effect. The dependent variable was measured by the self-reported cancer status. Data was summarized using frequencies, percentages, mean, SD, chi square, multinomial logistic regression. The mean age of the respondents was 47.9±10.1, 85.6% live in Nigeria, 7.6% in Cameroon and 6.8% live in the United States. Nearly 94% are employed and 15.7% achieved Post- secondary education. About a quarter (26 %) smoke. Among the smokers, 43.1% have smoked at least 100 cigarettes in their lifetime. Fifteen percent (15%) were exposed to second-hand smoke and 57.1% of them had high exposure. Nearly half (50%) of the respondents consumed alcohol, 79.4% of them consumed at a higher status. Thirty-nine percent (39%) have worked as an agricultural worker, among those, 16.4% have high exposure to chemicals fertilizers or pesticides. Majority of the respondents consumed food with positive (95.3%) and negative (81%) health outcomes. Nearly 97% of the respondents have never been diagnosed with cancer and 2.2% were diagnosed with Prostate cancer. No significant relationship was observed among smoking behavior (p=0.552), medication use (urinary retention p=0.486), dietary (negative health benefits p=0.308) and cancer status. In the multiple logistic regression only exposure to chemical fertilizers or pesticides was associated with of CaP status (P= 0.008). Working on the farm or as a grounds-man for 10 years or more and using chemicals and or pesticides increase the odds of developing CaP (OR= 2.6, 95% CI 0.015, 0.104). Only those who are exposed to pesticides and chemical fertilizers were more likely to develop prostate cancer. Citation Format: Hens Laurent, Catherine Oladoyinbo. Medication use and environmental risk factors associated with prostate cancer among West African men [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-140.