Abstract PO-186: Disparities in incidence of early- and late-onset lung cancer among Asians and Pacific Islanders (API) Populations in Guam, Hawai’i, and the United States.

Abstract

Abstract Lung Cancer is the most common cancer worldwide and the number one cause of cancer deaths in both men and women in the US and in Guam. However, incidence rates vary between ethnic groups and location. The objective of the study was to compare cumulative incidence rates (CIRs) among ethnic groups in Guam, Hawai’i, and the US; specifically, Chamorros in Guam, Filipinos in Guam, Hawai’i and the US, and Native Hawaiians in HI and the US. This study included all lung and bronchus cancer cases (n=474,558) reported to the Guam Cancer Registry and all lung cancer and bronchus cases (n=859) reported to the Surveillance, Epidemiology, and End Results (SEER) 9-Registry from 2000 to 2014. Trends in incidence were analyzed for early-onset (age<50; EO) and late-onset (age 50+; LO) cases by gender, ethnicity and location. For all three time periods: 2000-2004, 2005-2009, 2010-2014, EO lung cancer incidence rates were highest on Guam (5.1, 4.2 and 2.9 respectively) followed by Hawai’i (2.9, 2,9, and 1.9), followed by the US (3.1, 2.7, 2.1). Chamorro males on Guam have the highest EO incidence rates among all ethnic groups and locations and 8.1 times higher than Filipino males on Guam. EO lung cancer incidence decreased for males in all locations and all ethnic groups over the 3 times periods. Similarly, Chamorro females have the highest EO incidence rates and 7.4 times higher than Filipino females. EO lung cancer incidence decreased for females in all locations and all ethnic groups except for Filipino females in Hawai’i. For this group the incidence rate increased from 2.3 in 2000-2004 to 3.9 in 2010-2014. LO incidence rates reveal similar patterns. The rates decreased for both genders in all locations and all ethnic groups except for Filipino males and Filipino females in Hawai’i. Interestingly, there are big differences in lung cancer incidence rates between Filipinos in Hawai’i, Filipinos in the US and Filipinos on Guam. Filipinos in Hawai’i have the highest rates both for EO and LO and for both genders. Conclusions This data suggests that there are disparities in incidence of EO and LO lung cancer among different ethnic groups and even among different locations for the same ethnic group. Further study is needed to examine how the changes to the exposure to risk factors (smoking) contribute to the incidence disparities. Citation Format: Grazyna Badowski, Jaelene Renae Manibusan, Regina-Mae Dominguez, Trisha Mae Togawa. Disparities in incidence of early- and late-onset lung cancer among Asians and Pacific Islanders (API) Populations in Guam, Hawai’i, and the United States. [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-186.