Abstract PO-129: Influence of triple-negative versus Luminal A breast cancer subtype on choice of autologous versus implant based delayed-immediate breast reconstruction

Abstract

Abstract Background: Triple-negative and luminal A breast cancer molecular subtypes have divergent clinical and prognostic characteristics for breast cancer patients. Our study aims to compare the reconstructive choice of these two groups from the time they receive a tissue expander to the time they complete autologous or implant-based breast reconstruction. Methods: 255 patients who underwent delayed-immediate breast reconstruction with tissue expander placement from 2013 to 2017 diagnosed with either TN (n = 73) or luminal A (n = 182) invasive breast cancer subtype seen by two surgeons at a single institution were identified. Preference of autologous and implant- based reconstruction was analyzed, along with tissue expander (TE) complications, race, age, BMI, smoking, adjuvant therapy, and comorbidities. Results: There was a significant difference in the choice of implant- or autologous-based reconstruction among these two groups (p < 0.05). A greater proportion of luminal A patients underwent implant-based reconstruction (63.47%) and a greater proportion of TN patients underwent autologous-based reconstruction (53.13%). With regard to TE outcomes, there was no significant difference between the two groups with regard to duration of TE placement by reconstructive type, or TE surgical complications. Significantly more TN patients underwent radiation therapy (p < 0.01) and neoadjuvant chemotherapy (p < 0.0001) than luminal A patients. BMI, comorbidities, radiation therapy and overall TE complications were identified as predictive factors of patients electing for autologous reconstruction over implants. Conclusion: TN breast cancer patients mostly chose autologous-based reconstruction, while luminal A patients chose implant-based reconstruction. Both patient groups carried their tissue expanders for similar duration with similar complication profile. Radiation therapy is likely a major factor in the decision for the type of delayed-immediate reconstruction among this population. Citation Format: Joshua Amaya, Ryan M. Dickey, Kaitlin Jones, Sumeet S. Teotia, Nicholas T. Haddock. Influence of triple-negative versus Luminal A breast cancer subtype on choice of autologous versus implant based delayed-immediate breast reconstruction [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-129.