Abstract PD08-10: Breast Cancer Survivors Healthy Lifestyle Study: A Randomised Controlled Pilot To Test the Effects of a Behavioural Intervention (Information and Advice) on Uptake of Physical Activity in Breast Cancer Survivors

Abstract

Abstract Background: Physical activity (PA) is a potentially modifiable behavioural risk factor for breast cancer recurrence. It declines during treatment, and most breast cancer survivors do not engage in PA at recommended levels. Effective interventions to increase PA after primary treatment for early stage breast cancer are needed. Materials and Methods: Between November 2008 and January 2010, women who had completed primary treatment for early stage breast cancer, and not currently meeting PA guidelines, were randomly assigned to one of three conditions; 1) control group (UC) received a self-care fact sheet, or an intervention group 2) which received a theory based information booklet, diary and pedometer (INFO), or an alternate intervention group 3) which also received theory based information, diary and pedometer combined with a behavioural planning intervention (INFO+BPI). Measures (self reported PA, six minute walk test, mood, and quality of life) were collected at baseline (T1) and at 12 weeks (T2). The primary endpoint was self reported minutes of moderate to strenuous PA per week, secondary endpoints included mood and quality of life. A linear mixed models analysis approach was used to analyse data. Results: 118 women were randomized and 107 completed T2 measures. The average age of participants was 54.6 years (Range 32-74), 31.8% had stage I disease, 38.3% had stage II disease, 15% had stage IIIa disease and 15% had DCIS, 58% had received adjuvant chemotherapy. Motivation (intention) to increase PA did not differ between groups at T1. There were no differences between groups in PA at T1. PA levels increased in all groups between T1 and T2 (P<0.0001), but PA in the two intervention groups increased significantly more than in controls (+113.9 and +139.9 min per week increase in INFO and INFO + BPI respectively compared to +61.3 min per week in UC), such that at T2, there was a statistically significant difference between the intervention groups versus controls with +65 min per week increase on average (95% CI 25.3 to 104.8, p=0.02). There was no significant difference between the two intervention groups, with +25.9 min difference on average (95% CI -73.4 to 21.6, p=0.25). There were no significant differences in quality of life, anxiety or depression between groups at T1. No adverse events were reported. Discussion: Minimally intensive, theory-based interventions increased PA participation over a 12 week period in this single centre study. The addition of a behavioural planning intervention to the INFO intervention did not significantly improve PA participation. Results of a T3, 12 month, follow up will be important in determining sustainability of the behaviour change following these interventions. A larger multicentre study is warranted to confirm the efficacy of the intervention. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD08-10.