Abstract P718: The Relationship Between Abdominal Obesity and Quality of Life and Recurrence After First-Ever Ischaemic Stroke: A Hospital-Based Prospective Study

Abstract

Background and Objective: Both quality of life (Qol) and stroke recurrence are prognostic indicators for stroke survivor in different aspects. Studies have analyzed Qol and survival outcomes at the same time were sparse. And the comprehensive impact of abdominal obesity on Qol and recurrence remains unclear. The purpose of this study was to explore the comprehensive effect of abdominal obesity on the Qol and recurrence among ischaemic stroke survivors in China. Methods: Baseline information was collected with face-to-face interviews, Qol and obesity status for each patient were obtained through every 3 months via telephone follow-up, from 2010 to 2018. Qol was evaluated with the 12-item Short-Form Health Survey (SF-12), consists of physical component summary scores (PCS) and mental component summary scores (MCS). WC (waist circumference) were 2 categories (normal WC and abdominal obesity), according to Chinese-specific criteria. After establishing the linear mixed effect model and spline-PH model by R software, joint model model was used to explore the comprehensive effect of abdominal obesity on the Qol and recurrence. Results: According to the inclusion and exclusion criteria, 894 subjects were included in the study. At baseline, subjects were aged 17 to 89 years, and 487(54.47%) were abdominal obesity. During the study period, 195 (21.81%) patients recurred. Controlling for comorbidity and socio-demographic characteristics, abdominal obesity have similar effect on Qol and recurrence (overall effect: 0.162; HR: 1.176; 95%CI: 0.877~1.579). Similar results were obtained, when analysis of both PCS and recurrence (overall effect: 0.141; HR: 1.151, 95%CI: 0.857~1.547). As for the comprehensive effect on MCS and recurrence, abdominal obesity got higher risk than normal WC (overall effect: 1.280; HR: 3.597, 95%CI: 1.555~8.317). Conclusion: abdominal obesity increased comprehensive risk of MCS and recurrence, and abdominal obesity may have greater impact on the MCS of stroke survivors than PCS.