Abstract P610: Ten-Year International Temporal Variations in Age-Standardized Stroke-Related Mortality in Men and Women

Abstract

Background: Stroke is one of the leading causes of mortality worldwide. During the last decade, there have been several improvements in stroke-related care such as raising public awareness for early presentation, lifestyle modification, thrombolytic therapy and endovascular therapy. We aimed to evaluate the potential changes in global stroke-related mortality following these innovations. Methods: We completed a systematic review of all population-based cohort studies published during the last two decades (2000-2020). We retained all studies which reported age-adjusted and sex-specific stroke-related mortality. We grouped the countries into: developed countries with predominant White population* (Canada, United States of America, Western Europe, Australia, New Zealand), Eastern Europe, Latin America, and Asia. For each of the region, we compared the median stroke-related mortality during the decade 2010 to the stroke-related mortality of the 2000 decade. Results: Of 210 articles screened, there were eight studies that reported population-based age-standardized and sex-specific stroke-related mortality in 47 countries. We presented the international secular variations in sex-specific stroke-related mortality in Figure 1. We noted significant temporal decreases in age-standardized stroke-related mortality for both men and women in all regions except for Eastern European women and Asian men. Globally, the stroke-related mortality decreased from 40.0 to 31.7 and from 31.6 to 22.8 per 100,000 for men and women, respectively The reductions of stroke-related deaths approximated 22% and 29%, for men and women, respectively. Conclusion: Despite its temporal decrease in most regions, the lack of reduction in stroke-related mortality of Eastern European women and Asian men are noteworthy. Future research is needed to decrease the stroke-related mortality in these high-risk populations. *: As defined by the International Monetary Fund