Abstract P566: Prevalence of Renal Failure in a Young Community-Based Sub-Saharan African Population

Abstract

Background: Patients with renal failure have a higher risk or cardiovascular events. However, the prevalence of renal failure in Sub Saharan Africa communities remain poorly documented. Methods: Data were collected between March and April 2013 from 3 regions of the Northern Senegal (i.e., Saint-Louis, Matam et and Louga) using a cluster sampling method and the survey base of the national statistical and demographical agency subjects aged between 18 and 80 years. However, the present study focused on adult populations below 40 years of age. Participants underwent a face-to-face questionnaire to collect demographics and data on cardiovascular history/risk factors. Blood pressure and anthropometric measurements were performed in addition to blood tests including plasma creatinine. Renal failure was defined as a GFR < 60 ml/min/1.73 m 2 using the MDRD method adapted to the African population. Continuous data were reported as mean ± standard deviation (SD). Comparisons used the χ2 test for categorical variables and Student’s t test for continuous variables. Multiple logistic regression was used to identify factors associated with CFI, after considering potential confounders. Covariates with significant association (P<0.05) in univariate analysis were included in the multivariate logistic model. Results: Among the 2440 subjects in this study the mean age was 44 ± 15.99, 692 (28%) were male. Among the 1080 participants who were aged less than 40 years old (mean: 31 ± 7.54), 296 (27.4%) were male. Body mass index higher than 25 was present in 32% of the studied population with a significant increase in women (38% vs 15%, p<0,001). The prevalence of hypertension was 28%. The prevalence of renal failure was 3.1% (95%CI: 2.1-4.3%) with a mean glomerular filtration rate of 55 ± 23.58. None of the participants with renal failure had diabetes. Conclusion: This community-based cross-sectional study showed a low prevalence of renal failure in younger participants in Northern Senegal. Further investigations are needed to assess chronic kidney failure and its determinants.