Abstract P514: A Healthy Beverage Score and Risk of Chronic Kidney Disease Progression, Cardiovascular Disease, and All-Cause Mortality in the Chronic Renal Insufficiency Cohort

Abstract

Background: The association between an overall healthy beverage pattern and chronic disease outcomes is unknown. We created the Healthy Beverage Score (HBS) to characterize the healthfulness of participants’ beverage profiles and examined its association with chronic kidney disease (CKD) progression, cardiovascular disease (CVD), and all-cause mortality among individuals with CKD. Methods: We conducted a prospective analysis of 2,275 participants aged 21-74 years with an estimated glomerular filtration rate (eGFR) between 20 and 70 mL/min/1.73 m 2 from the Chronic Renal Insufficiency Cohort. Diet was assessed using a 124-item food frequency questionnaire at visit 1 (2003-2008). The HBS (7-28) consisted of 7 components. Each component was scored 1-4 based on rank distribution by quartile. Participants were given more points for higher consumption of low-fat milk, coffee and tea, moderate consumption of alcohol, and lower consumption of 100% fruit juice, full-fat milk, artificially-sweetened beverages, and sugar-sweetened beverages. CKD progression, CVD, and all-cause mortality were ascertained through January 2018. We conducted multivariable Cox proportional hazards models. Results: There were 815 cases of CKD progression, 285 cases of CVD, and 725 deaths over a median of 7, 10, and 12 years of follow-up, respectively. Compared with participants in the lowest tertile of the HBS, participants in the highest tertile had a 27% lower risk of CKD progression (hazard ratio, HR: 0.73, 95% confidence interval, CI: 0.61-0.87) ( P -trend<0.001) and 17% lower risk of all-cause mortality (HR: 0.83, 95% CI: 0.69-1.00) ( P -trend=0.05) after adjusting for covariates ( Table ). There was no significant association for CVD comparing tertile 3 with tertile 1 (HR: 0.93, 95% CI: 0.70-1.23) ( P -trend=0.70). Conclusions: A healthier beverage pattern was associated with lower risk of CKD progression and all-cause mortality. Beverage intake may be an important modifiable dietary target in managing outcomes for individuals with CKD.