Abstract P5-08-21: The effect of family history on screening procedures and prognosis in breast cancer patients – Results of a large population-based case–control study on breast cancer

Abstract

Abstract Background: Patients with a first- or second-degree family history of breast or ovarian cancer participate more frequently in breast cancer screening procedures. A benefit of additional screening visits has been documented in high-risk patients with (e.g. BRCA 1, BRCA 2 gene mutations). However, the potential benefit of additional screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear. Methods: Patients were recruited in 2002–2005 within a large population-based case–control study on breast cancer in Germany (3,813 cases and 7,341 age-matched healthy controls). Univariate and multivariate analyses were performed to evaluate the effect of family history on breast cancer risk, participation in screening procedures, tumor size and prognosis. Results A higher breast cancer risk was observed in patients with a positive family history (1 affected family member: OR 1.32, p<0.001). Patients with a 1st degree positive family history received a higher number of mammograms (MG) (>10 MG: 42.7% vs. 24.9%, p<0.001) and showed a higher rate of imaging-detected tumors (mammogram or ultrasound) (45.8% vs. 31.9%, p<0.001) compared to patients without positive family history. Positive family history (OR 1.45 pT1 vs. ≥pT2, p<0.001) and higher number of mammograms (≥10 mammograms: OR 2.29 pT1 vs. ≥pT2) were associated with smaller tumor size at initial diagnosis. Additionally, there was a significant association between mammogram regularity (HR 0.72, p<0.001) and imaging-assisted tumor detection (HR 0.66, p<0.001) with improved overall survival. However, no significant association between a positive family history of breast cancer and survival could be seen. Discussion: Patients with a family history of breast cancer participated more frequently in screening procedures and had a higher rate of image-detected tumors with smaller size at initial diagnosis, compared to patients without affected family members. Breast cancer screening procedures were significantly associated with improved survival. Citation Format: Seiffert K, Thoene K, zu Eulenburg C, Rudolph A, Schmalfeldt B, Flesch-Janys D, Chang-Claude J, Witzel I. The effect of family history on screening procedures and prognosis in breast cancer patients – Results of a large population-based case–control study on breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P5-08-21.