Abstract P5-01-01: The effectiveness of breast ultrasonography in cancer screening: A comparison with mammography

Abstract

Abstract Purpose Mammography(MMG) is a measure of screening that is proven to be effective in lowering death rate in breast cancer validated by randomized control trials. Recently, the number of incidence of breast cancer in Korean women is showing ascending tendency, and also as compared to those in North American and European countries, prevalence age tends to be lower. Since they tend to have much dense breast, MMG alone can hardly be considered as a sufficient measure of breast cancer screening. The purpose of the study is to study the effectiveness of breast ultrasonography(US) in breast cancer screening in Korean women by investigating the ratio of patients who are diagnosed as malignant in breast US over those who are diagnosed as negative or benign(category 1 and 2) and dense breast(category 0) in MMG. Materials and Methods We conducted the retrograde study over 2776 female subjects who had undergone screening MMG in single center in South Korea during the period between Jan, 1st 2010 to Dec, 31st 2016. Female patients are categorized according to BI-RAD category. 164 of subjects were previously undergone a breast cancer surgery, which made them eliminated from the list, and 2612 subjects are finally selected. Results Some more 33 subjects are excluded from the list and rest 2579 subject had undergone breast US. Among these, 1133 subjects (43.9%, 1133/2579) correspond to dense breast of BI-RADS category 0, while 303 of them are suspected of category 4 or more. The subjects corresponding to category 1 to 3 are 663, 251 and 229 respectively. 307 of 1133 subjects in category 0 are confirmed as having suspicious lesion based on findings of breast US. Among them, 66 subjects are identified as malignant based on biopsy, which accounts for 5.8% (66/1133). 104 subjects in category 1, are confirmed to have lesions based on findings of breast US, where 25 alone were identified as malignant (3.8%, 25/663). Likewise, 10 (4.0%, 10/251) in category 2 and 13 (5.7%, 13/229) in category 3 are identified. Subject categorization by BI-RAD systemCategory 0dense breast983 dense breast with calcification94 dense breast with probable mass28 others28 total113343.9%Category 1 66325.7%Category 2 2519.7%Category 3 2298.9%Category 4 or more 30311.7%total 2579100.0% Malignancy ratio of each category after biopsy totalsuspicious lesion on breast USbiopsy benignmalignantmalignancy ratioCategory 01133307241665.8% (66/1133)Category 1663104792525 3.8% (25/663)Category 22514131104.0% (10/251)Category 32297259135.7% (13/229) Conclusion It appears that 43.9% of total 2579 subjects undergone MMG and breast US are confirmed as dense breast in category 0 and 5.8% of them are diagnosed as breast cancer according to breast US and biopsy. Likewise, for those who are considered as either category 1 or 2, which is negative or benign lesion category, 3.8% are diagnosed as breast cancer. As it is appeared in this study, cancer detection can be more effective in parallel measure of MMG and breast US rather than MMG alone, especially for breast cancer screening of Korean female subjects. Citation Format: Jeong S, Kim Y, Kim K. The effectiveness of breast ultrasonography in cancer screening: A comparison with mammography [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-01-01.