Abstract P4-14-12: Influence of socio-economic deprivation score on outcomes for patients diagnosed with early breast cancer over a 9 year follow up at Kings College Hospital, UK

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Abstract Background: Socio-economic deprivation may have an influence on the outcome for patients diagnosed with breast cancer. The aim of this study was to investigate differences in survival outcome from breast cancer in women from different socio-economic backgrounds and to identify underlying factors that may contribute to any variation. Material and methods: This is a retrospective analysis of data from female patients diagnosed with early breast cancer at Kings College Hospital, a teaching hospital in London, UK between 2004 and 2012. For this study, mean, standard deviation, range and 50th percentile were calculated for the variables investigated. Incidence of death was estimated for deprivation quintile, ethnicity and year of diagnosis. The Cox proportional hazards model was used to estimate the relationship between survival and the several variables (deprivation, income score and ethnicity). The survival rates between levels of deprivation were compared using Kaplan Meier survival curve and log-rank test. Results: A total of 330 women with a diagnosis of early breast cancer were identified. Analysis of data on all patients (n=330) showed that the median survival time at which 50% of the patients survive is 4018 days (95% CI: 2556, 5479). Deprivation quintile ranged from levels 1 to 5 with level 1 defined as ‘affluent’ and level 5 being ‘most deprived’. These scores were reported for a total of 80 patients. Forty of these were alive and 40 had died from metastatic breast cancer. The two groups were matched for age, year of diagnosis and stage of disease. The highest incidence of death (19/33; 58%) was in level 5 of the deprivation quintile. There was no difference in patients’ survival rates between the 5 levels of the deprivation quintile. There was no difference between survival rates in white ethnic group compared with the black (χ2=0.03, p=0.86). There was no evidence of significance in relationship between hazard of death and deprivation in black and white ethnic groups. Similarly, there was no evidence of significance in relationship between hazard of death and income score in black and white ethnic groups. Adjusting for ethnicity also showed that deprivation and income score had no effect on hazard of death. Conclusion: According to our study higher degree of socio-economic deprivation is associated with higher mortality in breast cancer. Previous studies from different hospitals in UK have shown that black women have a significantly poorer outcome that white patients despite equal access to healthcare. Our study has shown that there is no correlation between ethnicity (white ethnic and black groups) and survival rates, hazard of death or deprivation in patients treated in Kings College Hospital. Citation Format: Olga Oikonomidou, Mercy Ofuya, Anne S Rigg. Influence of socio-economic deprivation score on outcomes for patients diagnosed with early breast cancer over a 9 year follow up at Kings College Hospital, UK [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-14-12.