Abstract P382: Association of Passive Smoking Status to Endothelial Vascular Function Among General Japanese Women

Abstract

Objective: Passive smoking was reported to impair endothelial vascular function in an acute phase. However, studies regarding the vascular effect of passive smoking status among general population are still scarce. We investigated the association of passive smoking status to endothelial vascular function among general Japanese women. Methods: Study participants were 243 Japanese women who had never smoked, and aged 69 to 85 years randomly selected from Kusatsu City, Japan. Using self-administered questionnaire, passive smoking status and passive smoking hour per week at recent 1 year and those of 20 years ago were obtained. They were classified into 4 groups (never, past, current; <2 hours/week, ≥2 hours/week). Endothelial vascular function was assessed with reactive hyperemia index (RHI) using Endo-PAT2000 (itamar-medical). RHI ≤1.67 were defined as low RHI. Age adjusted means of RHI according to passive smoking status was estimated. Simple liner regression analysis tested the association between RHI and traditional atherosclerotic risk factors such as age, body mass index (BMI), systolic and diastolic blood pressure, heart rate, lipids, fasting blood glucose and hemoglobin A1c. Age and multivariable adjusted odd’s ratios and 95% confidence intervals (OR, 95%CI) of passive smoking status for low RHI were estimated using logistic regression. Variables which showed statistical significant association to RHI in simple liner regression were adjusted. Results: Distribution of passive smoking status was; never 42.4%, past 42.0%, current <2 hours/week 6.5%, ≥2 hours/week 9.1%. Low RHI was confirmed in 41.2% of study participants. Age adjusted means of RHI did not differ significantly by smoking status (Age adjusted mean ± SD of RHI; never 1.94 ± 0.06, past 1.88 ± 0.06, current <2 hours/week 1.85 ± 0.15, ≥2 hours/week 2.15 ± 0.13, p=0.270). In simple liner regression analysis, BMI, diastolic blood pressure, heart rate and fasting glucose showed statistical significant association to RHI, and these variables were adjusted in multivariable adjusted logistic regression model. In logistic regression analyses, significant association of passive smoking status to low RHI was not confirmed [Age adjusted OR (95%CI); never (reference), past 1.00 (0.57-1.75), current <2 hours/week 1.45 (0.50-4.23), ≥2 hours/week 0.66 (0.25-1.76), multivariable adjusted OR (95%CI); never (reference), past 1.02 (0.57-1.82), current <2 hours/week 1.72 (0.57-5.21), ≥2 hours/week 0.61 (0.22-1.73)]. Conclusion: Passive smoking status was not associated to endothelial vascular function assessed with RHI among general Japanese women. Further investigation is still required.