Abstract
Introduction: Accumulating evidence suggests that prolonged sitting may have adverse effects on vascular health. Pulse wave velocity (PWV) is a simple measurement of vascular stiffness that would be advantageous to measure in a seated posture. However, the reliability and validity of PWV measured in a seated posture are unknown. Objective: To assess day-to-day reliability and validity of seated peripheral PWV. Methods: This randomized cross-over study (N=20, 50% male, mean (SD) age = 25.9 (7.7)) consisted of two experimental visits, conducted a maximum of 14 days apart. Outcome measures were carotid-radial PWV (crPWV), carotid-ankle PWV (caPWV), and carotid-femoral PWV (cfPWV; supine position only) by tonometry using the Complior Analyse System. Measurements were completed in both a supine and seated posture (counterbalanced), preceded by a 10-minute rest, and following a 12-hr abstention from food, caffeine, nicotine, alcohol, and exercise. Intra-class correlations (ICCs) assessed day-to-day reliability with ≥0.75 as the criterion for good reliability. Validity was determined by comparing (Pearson’s correlation) peripheral PWV measures in the seated compared to supine posture as well as to central PWV measures (supine cfPWV). Results: ICCs for crPWV were 0.64 (supine) and 0.77 (seated) and for caPWV were 0.36 (supine) and 0.76 (seated). Supine vs. seated peripheral PWV measures were highly correlated for crPWV but not correlated for caPWV ( Figure ). Comparison of supine cfPWV to seated peripheral PWV were r=0.483 ( p =0.031) for crPWV and r=0.386 ( p =0.103) for caPWV. Conclusion: While measures of seated crPWV and caPWV were both reliable and small-to-moderately correlated with related vascular measures, only seated crPWV was valid compared to the standard supine measure. Future studies evaluating the impact of prolonged sitting and breaking up prolonged sitting could consider measuring crPWV in a seated posture.
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