Abstract P371: The Effects of Omega-3 Fatty Acid Ethyl Esters on QT Dispersion and Corrected QT Dispersion in Hypertensive Patients With Left Ventricular Hypertrophy

Abstract

Background: Left ventricular hypertrophy (LVH) leads to arrhythmia such as atrial fibrillation, ventricular arrhythmias and known risk factor of sudden cardiac death. Recent study suggests that Omega-3 fatty acid ethyl esters have anti-arrhythmic effects and reduce sudden cardiac death among survivor of myocardial infarction. QT dispersion(QTD) reflects ventricular repolarization heterogeneity and prolonged QTD has been associated with the risk of arrhythmic death in coronary artery disease patients. However, no study has done to prove the effects of Omega-3 fatty acid ethyl esters on QTD and corrected QTD(cQTD) in hypertensive patients with LVH Objective: We tried to evaluate the effects of Omega-3 fatty acid ethyl esters on QTD and cQTD in hypertensive patients with LVH Design and Method: This study included 30 hypertensive patients who confirmed LVH by ECG voltage criteria. The patients were evaluated with 12-leads electrocardiography before and 3~6 months after treatment of Omega-3 fatty acid ethyl esters(1g/day). We measured QTD (maximal QT interval - minimal QT interval) and cQTD (maximal corrected QT interval - minimal corrected QT interval) by Bazett’s formula using electronic caliper before and after treatment. Results: QTD (before: 60.86±14, after: 51.84±13.95 P=0.003) and cQTD (before: 63.83±14.18, after: 51.83±13.94 P<0.001) was significantly reduced after treatment of Omega-3 fatty acid ethyl esters Conclusions: The QTD and cQTD significantly reduced after treatment of Omega-3 fatty acid ethyl esters in hypertensive patients with LVH. It may partially explain the anti-arrhythmic effect of Omega-3 fatty acid ethyl esters.