Abstract
Background: In hypertensive patients, it is well-known that PWD (P wave dispersion = maximal P wave duration - minimal P wave duration) is associated with the level of BP and the level of PWD correlates with the prevalence of arrhythmias and left atrial enlargement in previous studies. Fixed-dose combination(FDC) of anti-hypertensive agents effectively lower BP compared with free-drug combination. There have been some studies comparing the effect of anti-hypertensive agents on P-wave parameters. However, there have been no studies assessing the change of PWD after switching anti-hypertensive agents from free drug combination into fixed-dose combination Objective: The aim of this study was to assess the change of PWD after switching anti-hypertensive agents from free drug combination of angiotensin II receptor blocker(ARB)/Calcium channel blocker(CCB) into fixed-dose combination Design and Method: This study included 20 patients who changed anti-hypertensive agents from free drug combination of ARB/CCB into same dosage fixed-dose combinations (FDCs) of ARB/CCB during 2011 to 2014. The maximal P wave duration(maxPWD), minimal P wave duration(minPWD), P wave dispersion(PWD), cPWD(corrected by heart rate, i.e. corrected P wave dispersion) measured by 12-lead electrocardiogram(ECG) at a paper speed of 50mm/s and 20mm/mV Results: The PWD was reduced non-statically after changed into fixed dose combination (54.45±13.14ms) compared with free drug combination (56.73±11.90ms, p=0.070). The cPWD was reduced statically after changed into fixed dose combination (56.72±11.90ms) compared with free drug combination (60.02±12.28ms, p=0.003). Conclusions: The cPWD significantly reduced after switching anti-hypertensive agents from free drug combination into fixed dose combination
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