Abstract P361: Cardiovascular Health in South Asian American Adults in the MASALA Study: Updated Metrics Using the Life’s Essential 8 Definitions

Abstract

Introduction: The AHA Life’s Simple 7 (LS7) score was recently updated to the Life’s Essential 8 (LE8) score which revised cardiovascular health (CVH) scoring, including accounting for Asian-specific body mass index, secondhand smoke exposure, and sleep. We evaluated CVH in South Asian American participants of the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Methods: At the MASALA baseline exam, median LE8 CVH score was calculated across levels of the LS7 score. Age- and sex-adjusted mean LE8 CVH score was compared by income, education, and country of birth using linear regression. Logistic regression evaluated the age- and sex-adjusted association of LE8 CVH with prevalent coronary artery calcium (CAC) score greater than 0. Sleep duration was not available, so the LE8 score was calculated with the 7 original CVH factors. Results: Among 1,093 South Asian American adults in the MASALA Study (48.5% female, mean age 56.7 [SD 9.4] years), mean LE8 CVH score was 68.7 (SD 11.6). The LE8 and LS7 CVH scores were significantly correlated (r=0.78, p<0.01). Median (interquartile range) LE8 score across levels of LS7 score is shown in the Figure. Mean adjusted LE8 score was significantly higher (p<0.01) among those with annual income ≥$75,000 vs. <$75,000 (70.0 [11.6] vs. 65.7 [10.9]) and those with more vs. less than college education (69.5 [11.3] vs. 67.7 [11.8]). Mean LE8 scores significantly varied by place of birth (Bangladesh 69.3 [14.8]; India 69.2 [11.3]; Pakistan 61.0 [11.7]; Sri Lanka 63.9 [11.7]; United States 68.2 [13.7]; p<0.01). A 10-point higher LE8 score was associated with lower odds of prevalent CAC (OR 0.67 [95% CI 0.58-0.76]). Odds of any CAC was higher for participants with low (score 0-49) or moderate (score 50-80) vs. high (score 80-100) CVH (low: OR 5.43 [2.51-11.77]; moderate: OR 3.23 [2.07-5.06]). Conclusions: The LE8 CVH score is highly correlated with the LS7 CVH score among South Asian American adults, varies across sociodemographic factors, and is associated with odds of prevalent CAC.